Technology or method
Sequence alignment
Lining up DNA or protein sequences to find similarities. Dynamic programming finds the best global or local alignment.
Substitution matrices
Scores for replacing one amino acid with another, such as BLOSUM, used when aligning proteins.Source: Henikoff & Henikoff, 1992
Also called BLOSUM62.
Idea or model
How Substitution matrices connects
Substitution matrices is used by
Studied in
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Sources & further reading
The explanations on this page are our own summaries of these sources. Follow a link to read the original; if anything here disagrees with it, the original wins. How we choose and check sources.
Amino acid substitution matrices from protein blocks (opens the original in a new tab)
Henikoff S, Henikoff JG (1992). Proceedings of the National Academy of Sciences 89:10915-10919.
Peer-reviewedPrimary research